Antisense oligonucleotides and uses thereof

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United States of America Patent

PATENT NO 11672816
SERIAL NO

16982167

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Abstract

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Disclosed herein are novel compounds comprising antisense oligonucleotides that regulate the splicing of NUMB. In particular, an antisense oligonucleotide for reducing inclusion of NUMB exon 9 in a population of mature NUMB transcripts is provided. The antisense oligonucleotide comprises a sequence of at least 7 nucleotides that is complementary to a target region within exon 9 of a NUMB transcript. Pharmaceutical compositions comprising the antisense oligonucleotide and methods of treating a proliferative disease using the compounds or compositions of the invention are also described.

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Patent Owner(s)

Patent OwnerAddress
FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III (F S P CNIO)28029 MADRID

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bechara, Elias Barcelona, ES 2 0
Fernández, Marcos Pablo José Las Rozas, ES 2 0
Hernández, Ribera Jordi Barcelona, ES 2 0
Rovira, Del Olmo Miguel Madrid, ES 2 0
Serrano, Marugán Manuel Tres Cantos, ES 2 0
Valcárcel, Juárez Juan Alberto Barcelona, ES 2 0

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