Production of erythropoietin by endogenous gene activation
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United States of America Patent
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May 21, 2002
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app pub date -
Jan 21, 2000
filing date -
Jul 23, 1997
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Abstract
The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO inhuman cells, and a method for the large technical production of EPO in human cells.
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