Methods for epicardial differentiation of human pluripotent stem cells

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United States of America Patent

PATENT NO 11591569
APP PUB NO 20190085293A1
SERIAL NO

16156677

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Abstract

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Methods for generating high-yield, high-purity epicardial cells are described. Wnt/β-catenin signaling is first activated in human cardiac progenitor cells, by, for example, inhibiting Gsk-3 to induce differentiation into epicardial cells. Methods for long-term in vitro maintenance of human cardiac progenitor cell-derived epicardial cells and method comprising chemically defined, xeno-free, and albumin-free culture conditions are also provided.

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Patent Owner(s)

  • - WISCONSIN ALUMNI RESEARCH FOUNDATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bao, Xiaoping Madison, US 7 18
Lian, Xiaojun Solna, SE 12 72
Palecek, Sean P Verona, US 23 185

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