Pharmaceutical formulations of tropomyosin related kinase (TRK) inhibitors

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United States of America Patent

PATENT NO 11110055
SERIAL NO

16239904

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Abstract

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Pharmaceutical formulations with a tropomyosin-related kinase inhibitor (“Trk inhibitor”) are disclosed. The pharmaceutical formulations comprise 3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine in microcrystalline suspension formulations in its monohydrate form, which shows improved characteristics over the anhydrate form, and in extended release formulations. The extended release pharmaceutical formulations comprise 3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine-loaded microspheres.

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Patent Owner(s)

  • GENZYME CORPORATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ho, Chris Bridgewater, US 21 116
Lieberman, Harvey Bridgewater, US 4 11
Philbrook, C Michael Boston, US 16 898
Santos, Michael Cambridge, US 17 211
Yang, Donglai Bridgewater, US 18 142

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