Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites

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United States of America Patent

PATENT NO 11866726
APP PUB NO 20200165636A1
SERIAL NO

16630510

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Abstract

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Disclosed herein are genome editing systems and related methods which allow for the detection and quantitative measurement of all possible on-target gene editing outcomes, including targeted integration. The compositions and methods described herein rely on the use of donor templates comprising a 5′ homology arm, a cargo, a one or more priming sites, a 3′ homology arm, and optionally stuffer sequence.

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Patent Owner(s)

Patent OwnerAddress
EDITAS MEDICINE INC11 HURLEY STREET CAMBRIDGE MA 02141

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cotta-Ramusino, Cecilia Cambridge, US 16 82
Margulies, Carrie M Waban, US 3 0

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