Method of conferring immuno-tolerance to a specific antigen
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United States of America Patent
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Feb 27, 1990
Issued Date -
N/A
app pub date -
Mar 20, 1987
filing date -
Apr 17, 1985
priority date (Note) -
Expired
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Abstract
A method of selectively suppressing the immune system and conferring immunotolerance against a specific antigen by interferring with the L3T4 differentiation antigens on helper T cells is described. Simultaneous administration of a binding moiety specific for the L3T4-equivalent in the subject species and a specific antigen or administration of the antigen subsequent to the binding moiety for L3T4-equivalent within the time required for T-cell recovery results in a diminished ability of the subject to respond immunologically to the antigen, whether or not the subject has been exposed previously to the antigen.
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