DNA polymerase variants with reduced exonuclease activity and uses thereof

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United States of America Patent

PATENT NO 8921043
APP PUB NO 20130196327A1
SERIAL NO

13822724

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Abstract

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Compositions and methods are described to modify Family B DNA polymerases that contain residual exonuclease activity that interferes with sequencing techniques and with detection of single nucleotide polymorphisms. The compositions are mutant proteins with reduced exonuclease activity compared with presently available “exo−” polymerases, and a sensitive screening assay that enables an assessment of exonuclease activity of any synthetic DNA polymerase.

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Patent Owner(s)

  • NEW ENGLAND BIOLABS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gardner, Andrew Manchester, US 24 122

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