Composition comprising fluriprofen and effectively non-antibacterial tetracycline to reduce bone loss
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United States of America Patent
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Jun 14, 1994
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N/A
app pub date -
Aug 12, 1991
filing date -
Dec 4, 1989
priority date (Note) -
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Abstract
A method for treating mammals suffering from rheumatoid arthritis and other tissue-destructive (chronic inflammatory or other) conditions associated with excess metalloproteinase activity comprising administering to the mammal an amount of a tetracycline that is effectively anti-metalloproteinase, but that is not effectively antimicrobial, and an amount of non-steroidal anti-inflammatory agent which, when combined with the effectively anti-metalloproteinase amount of tetracycline, results in a significant reduction of tissue destruction and/or bone loss.
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