Artificial lung of membrane type
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United States of America Patent
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Nov 22, 2005
Grant Date -
Apr 3, 2003
app pub date -
Sep 28, 2001
filing date -
Sep 28, 2001
priority date (Note) -
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Abstract
A membrane artificial lung performs gas exchange between blood and a gas via the membrane by flowing the blood in one side of the membrane and flowing oxygen or an oxygen-containing gas in the other side of the membrane. The membrane has a hollow fiber membrane of poly-4-methylpentene-1 and an oxygen permeation rate Q(O2) at 25° C. of from 1×10-6 to 3×10-3 (cm3(STP)/cm2·sec·cmHg) and an ethanol flux of from 0.1 to 100 ml/min·m2. The membrane has, in the side of the blood flow, a surface having an ionic complex derived from: quaternary aliphatic alkylammonium salts; and heparin or a heparin derivative. The quaternary alkylammonium salts are a quaternary aliphatic alkylammonium salt having from 22 to 26 carbon atoms in total and a quaternary aliphatic alkylammonium salt having from 37 to 40 carbon atoms in total.
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