Continuous process for reducing heterogeneity of therapeutic protein

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United States of America Patent

PATENT NO 11618768
APP PUB NO 20190263855A1
SERIAL NO

16340822

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Abstract

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The present disclosure relates to a bio-manufacturing process that enables continuous production of a therapeutic protein with reduced heterogeneity. The bio-manufacturing process disclosed herein utilizes a multi column chromatography system that performs the unit operations of reducing heterogeneity in a therapeutic protein, capturing the therapeutic protein and inactivating viruses, purifying the therapeutic protein, and polishing the purified therapeutic protein. The process disclosed herein can reduce heterogeneity of a therapeutic protein by reducing a proportion of basic isoforms of the therapeutic protein.

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Patent Owner(s)

  • ENZENE BIOSCIENCES LIMITED

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Banerjee, Abir Pune, IN 5 12
Dyaga, Gopal Pune, IN 1 0
Gadgil, Himanshu Pune, IN 11 28
Londhe, Harshita Pune, IN 4 0
Pankhania, Ashvin Pune, IN 1 0
Rao, Deepika Pune, IN 1 0

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