Macrocyclic chelators and methods of use thereof

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United States of America Patent

PATENT NO 11576986
APP PUB NO 20200353105A1
SERIAL NO

16869771

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Abstract

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Macrocyclic chelators for chelation of alpha-emitting radiometal ions, such as actinium-225 are provided. Also provided are radiometal complexes containing an alpha-emitting radiometal ion bound to the macrocyclic chelator via coordinate bonding, and radioimmunoconjugates containing the radiometal complexes covalently linked to a targeting ligand, such as an antibody or antigen binding fragment thereof. The radioimmunoconjugates can be produced by click chemistry reactions. Methods of using the radiocomplexes and radioimmunoconjugates for selectively targeting neoplastic cells for radiotherapy and for treating neoplastic diseases and disorders are also described.

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Patent Owner(s)

  • JANSSEN BIOTECH, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dudkin, Vadim Chalfont, US 19 99
Goldberg, Shalom Merion Station, US 16 54
Keith, John San Diego, US 43 88
Salter, Rhys Doylestown, US 39 365
Song, Fengbin Doylestown, US 11 31
Zhang, Wei Malvern, US 2317 17796

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