17,20(E)-dehydro vitamin D analogs and their uses
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United States of America Patent
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Jul 10, 2007
Grant Date -
May 25, 2006
app pub date -
Nov 18, 2005
filing date -
Nov 22, 2004
priority date (Note) -
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Abstract
This invention discloses 17,20(E)-dehydro vitamin D analogs, and specifically 17(E)-1.alpha.,25-dihydroxy-17(20)-dehydro-2-methylene-19-nor-vitamin D.sub.3 and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders and inflammatory diseases in humans as well as renal osteodystrophy and obesity.
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