TNF-derived peptides for use in treating oedema
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United States of America Patent
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Aug 21, 2007
Grant Date -
Oct 2, 2003
app pub date -
Jun 6, 2002
filing date -
Aug 14, 1998
priority date (Note) -
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Abstract
The present invention is based on the finding that peptides derived from a specific domain of tumor necrosis factor-alpha (TNF-.alpha.) can efficiently be used to treat oedema. More specifically, the present invention relates to the usage of peptides derived from the region of human TNF-.alpha. from Ser.sup.100 to Glu.sup.116 to treat pulmonary oedema. For example, the circularized peptide having amino acid sequence CGQRETPEGAEAKPWYC is shown to be very efficient in inducing oedema resorption.
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