P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD

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United States of America Patent

PATENT NO 10342786
APP PUB NO 20190105311A1
SERIAL NO

16166031

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Abstract

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The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed.

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FULCRUM THERAPEUTICS INC26 LANDSDOWNE ST CAMBRIDGE MA 02139

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cacace, Angela Marie Haddam Neck, US 8 9
Chang, Aaron Nakwon Lexington, US 8 8
Robertson, Alan Scott Cambridge, US 7 8
Rojas, Soto Luis Gustavo Alejandro Cambridge, US 7 9
Ronco, Lucienne V Wellesley, US 7 8
Shen, Ning Cambridge, US 21 63
Thompson,, III Lorin A Cohasset, US 45 126
Wallace, Owen Brendan Brookline, US 39 178

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