Cell culture system for synthesis of infectious hepatitis C virus
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United States of America Patent
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Feb 27, 2007
Grant Date -
Dec 26, 2002
app pub date -
Mar 11, 2002
filing date -
Mar 9, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention rates to a hepatitis C virus (HCV) cDNA-based culture system capable of synthesis of infectious HCV in cell culture and cell-to-cell spread of the virus. The invention also relates to a method of measuring the level of HCV infection in a hepatocyte cell. A method for identifying a modulator of HCV activity is also presented, and a method for modulating HCV activity. The invention provides a reliable system for both genetic analysis of the viral genome and for the development of novel antiviral strategies.
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