Therapeutic targeting of the BAP1 complex in cancer

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United States of America Patent

PATENT NO 11672794
APP PUB NO 20210060001A1
SERIAL NO

16931942

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Abstract

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Disclosed are methods for methods, compounds, and compositions for treating cancers characterized by therapeutic targeting of the BAP1 histone H2A deubiquitinase (DUB) complex, otherwise referred to herein as the BAP1 complex. In particular, the methods, compounds, and compositions disclosed herein relate to the use of therapeutic agents that inhibit the biological activity of the BAP1 complex for treating cancers such as myeloid neoplasms.

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NORTHWESTERN UNIVERSITY633 CLARK STREET EVANSTON IL 60208

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Shilatifard, Ali Chicago, US 11 15
Wang, Lu Chicago, US 403 6282

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