Lipid membrane structure for delivery into siRNA cell

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United States of America Patent

PATENT NO 11517528
APP PUB NO 20200129431A1
SERIAL NO

16622109

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A lipid membrane structure includes, as lipid components, a lipid compound represented by Formula (I):

description='In-line Formulae' end='lead'(R1)(R2)C(OH)—(CH3)a—(O—CO)b—X  (I)description='In-line Formulae' end='tail'

    [in the formula, a represents an integer of 3 to 5; b represents an integer of 0 or 1; R1 and R2 each independently represents a linear hydrocarbon group that may have —CO—O—; and X represents a 5- to 7-membered non-aromatic heterocyclic group or a group represented by Formula (B) (in the formula, d represents an integer of 0 to 3, and R3 and R4 each independently represents a C1-4 alkyl group or a C2-4 alkenyl group, where, R3 and R4 may be bonded to each other to form a 5- to 7-membered non-aromatic heterocycle (where, one or two C1-4 alkyl groups or C2-4 alkenyl groups may be substituted on the ring)].

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Patent Owner(s)

  • NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Harashima, Hideyoshi Sapporo, JP 43 84
Sato, Yusuke Sapporo, JP 141 726

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