Isolated p27 protein

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United States of America Patent

PATENT NO 6355774
SERIAL NO

08854039

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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An isolated protein designated p27 is disclosed. The p27 protein has an apparent molecular weight of about 27 kD, and is capable of binding to and inhibiting the activation of a cyclin E-Cdk2 complex. A nucleic acid sequence encoding p27 protein is disclosed, as well as a method for producing p27 in cultured cells. In vitro assays for discovering agents which affect the activity of p27 are also provided. Methods of diagnosing and treating hypoproliferative disorders are provided.

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Patent Owner(s)

  • FRED HUTCHINSON CANCER RESEARCH CENTER;GPC BIOTECH INC.;MEMORIAL SLOAN-KETTERING CANCER CENTER;SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Koff, Andrew New York, NY 14 209
Massague, Joan New York, NY 27 221
Polyak, Kornelia Baltimore, MD 25 197
Roberts, James M Seattle, WA 30 289

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