Device and method for intracellular delivery of biomolecular cargo via acoustic wave exposure

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United States of America Patent

PATENT NO 11684922
SERIAL NO

16485424

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Abstract

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A microfluidic-based device and system is disclosed for the high-throughput intracellular delivery of biomolecular cargo to cells (eukaryotic or prokaryotic) or enveloped viruses. Cargo integration occurs due to transient membrane permeabilization by exposure to bulk acoustic waves (BAWs) transduced from surface acoustic waves (SAWs) generated by a rapidly oscillating piezoelectric substrate. In this approach, temporary pores are established across the cellular membrane as cells are partially deformed and squeezed or subject to shearing forces as they travel through the vibrational modes created within the microfludic channel(s) of the device.

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Patent Owner(s)

  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Belling, Jason Los Angeles, US 1 1
Jonas, Steven J Hawthorne, US 16 108
Stieg, Adam Z Pasadena, US 1 1
Weiss, Paul S Los Angeles, US 29 385
Wilkinson, Dan New York, US 1 1

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