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Abstract

A method of treatment of visceral pain in mammals, including humans, which method comprises the administration to the mammal in need of such treatment, an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof: X--CO--Y--Z (I) wherein X is a group of formula (a), (b), (c), (d) or (e): ##STR1## wherein R.sub.a to R.sub.d are selected from hydrogen, halogen or hydroxy; R.sub.1 is hydrogen and R.sub.2 is hydrogen or C.sub.1-4 alkyl; or R.sub.1 and R.sub.2 together are a bond; R.sub.3 to R.sub.7 are independently hydrogen or C.sub.1-6 alkyl; and R.sub.4 together with R.sub.2 may be C.sub.2-7 polymethylene when R.sub.1 is hydrogen; either R.sub.8 is C.sub.1-6 alkoxy; R.sub.9 is hydrogen; R.sub.10 is amino or C.sub.1-7 alkanoylamino; and R.sub.11 is halo or C.sub.1-6 alkylthio; or R.sub.8 is hydrogen; R.sub.9 is halo, C.sub.1-6 alkoxy or C.sub.1-6 alkyl; R.sub.10 is hydrogen or C.sub.1-6 alkoxy; and R.sub.11 is halo, C.sub.1-6 alkoxy or C.sub.1-6 alkyl; L is CH or N; Y is NH or O, with the proviso that Y is NH when X is (e) and R.sub.8 is C.sub.1-6 alkoxy; Z is a group of formula (f), (g) or (h): ##STR2## wherein n is 2 or 3; p and q are independently 1 to 3; and R.sub.12 or R.sub.13 is methyl or ethyl.

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First Claim