Integrated functional and molecular profiling of cells

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United States of America Patent

PATENT NO 11774449
APP PUB NO 20210018503A1
SERIAL NO

16995559

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Presented herein are methods of evaluating cellular activity by: placing a cell population on an area; assaying for a dynamic behavior of the cell population as a function of time; identifying cell(s) of interest based on the dynamic behavior; characterizing a molecular profile of the cell(s); and correlating the obtained information. The assayed dynamic behavior can include cellular activation, cellular inhibition, cellular interaction, protein expression, protein secretion, cellular proliferation, changes in cellular morphology, motility, cell death, cell cytotoxicity, cell lysis, and combinations thereof. Sensors associated with the area may be utilized to facilitate assaying. Molecular profiles of the cell(s) can then be characterized by various methods, such as DNA analysis, RNA analysis, and protein analysis. The dynamic behavior and molecular profile can then be correlated for various purposes, such as predicting clinical outcome of a treatment, screening cells, facilitating a treatment, diagnosing a disease, and monitoring cellular activity.

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Patent Owner(s)

  • UNIVERSITY OF HOUSTON SYSTEM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liadi, Ivan Houston, US 3 1
Romain, Gabrielle Houston, US 7 7
Roysam, Badrinath Houston, US 4 11
Sendra, Victor Cambridge, US 2 1
Varadarajan, Navin Houston, US 12 19

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