Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
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United States of America Patent
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Sep 18, 2001
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Oct 2, 1998
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Feb 17, 1994
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Abstract
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
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