4[piperidin-4-yliden-(3-carbamoylpheny)methyl]benzamide derivatives and their use for the treatment of pain spinal injuries or gastrointestinal disorders
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United States of America Patent
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Apr 17, 2007
Grant Date -
Jan 27, 2005
app pub date -
Oct 2, 2002
filing date -
Oct 3, 2001
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Compounds of general formula (I) wherein R.sup.1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl and triazolyl; where each R.sup.1 phenyl ring and R.sup.1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C.sub.1 C.sub.6 alkyl, NO.sub.2, CF.sub.3, C.sub.1 C.sub.6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on thephenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, inparticular in the management of pain.
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