Influenza vaccine production in liquid cell culture
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United States of America Patent
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Feb 19, 1985
Issued Date -
N/A
app pub date -
Sep 29, 1982
filing date -
May 15, 1979
priority date (Note) -
Expired
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Abstract
Infectivity and replication of influenza viruses in successive numbers of cells of the same liquid cell culture is assured by including a protein hydrolyzing enzyme in the culture during virus incubation. Technique overcomes 'one-step growth cycle' of virus and allows commercial influenza vaccine production from liquid cell cultures instead of from more costly embryonated chicken eggs. Resulting vaccine is thus substantially free of egg proteins.
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