Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides

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United States of America Patent

PATENT NO 7696312
SERIAL NO

11874060

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Abstract

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Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

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Patent Owner(s)

  • AMBRX, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Driver, Russell Madison, US 20 869
Liu, Junjie San Diego, US 107 1444
Miao, Zhenwei San Diego, US 79 2043
Norman, Thea San Diego, US 56 1802

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