Cell-reactive, long-acting, or targeted compstatin analogs and related compositions and methods

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 11292815
APP PUB NO 20210032289A1
SERIAL NO

16912655

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Abstract

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In some aspects, the present invention provides compositions and methods (e.g. methods of treating, preventing, making, etc.) comprising compstatin analogs. In some embodiments, compstatin analogs comprise a linear PEG moiety having a molecular weight of 40 kDa and coupled to each of two compstatin analog moieties; wherein each compstatin analog moiety is a CA28-AEEAc-Lys moiety, the linear PEG moiety is coupled to the Lys side chain of each CA28-AEEAc-Lys moiety via a carbamate and each CA28-AEEAc-Lys moiety is Ac-Ile-Cys*-Val-(1Me)Trp-Gln-Asp-Trp-Gly-Ala-His-Arg-Cys*-Thr-[NH-CH2CH2OCH2CH2OCH2-C(═O)]-Lys-NH2 (SEQ ID NO: 51); wherein the Cys* groups are joined by a disulfide bond.

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Patent Owner(s)

  • APELLIS PHARMACEUTICALS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Deschatelets, Pascal West Newton, US 67 1011
Francois, Cedric Prospect, US 92 1882

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