EBNA2 peptides and methods of using same
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United States of America Patent
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Dec 19, 2000
Issued Date -
N/A
app pub date -
Aug 13, 1998
filing date -
Feb 13, 1996
priority date (Note) -
Expired
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Abstract
The present invention provides peptides having substantial homology with the CBF1/RBPJk interaction domain of EBNA2. The peptides preferably comprise between about ten and twenty amino acids. The peptides are able to compete with the native EBV EBNA2 protein for interaction with CBF1. The peptides thus can be employed as a pharmaceutical, e.g., along with an appropriate carrier in a pharmaceutical composition, particularly in a method of protecting against or treating EBV infection. The peptides also can be employed in a method of detecting factors that interact with the EBV EBNA2 protein.
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