Human NEDD8 activating enzyme 1 beta proteins and uses thereof
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United States of America Patent
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Jul 27, 2010
Grant Date -
May 10, 2007
app pub date -
Dec 14, 2006
filing date -
Dec 19, 1997
priority date (Note) -
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Abstract
The invention relates to covalent modification of proteins through their conjugation with other proteins. More particularly, the invention relates to the modulation of such conjugation involving the protein NEDD8. The invention provides compositions and methods for detecting and/or modulating the activation and/or conjugation of NEDD8, as well as compositions and methods for discovering molecules which are useful in detecting and/or modulating the activation and/or conjugation of NEDD8. The present invention arises from the purification and charactization of novel NEDD8 activating and conjugating enzymes.
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