Neuroprotective compositions and methods
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United States of America Patent
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Sep 20, 2011
Grant Date -
Feb 12, 2009
app pub date -
Oct 10, 2007
filing date -
Oct 10, 2006
priority date (Note) -
Expired
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Abstract
Neurite outgrowth-promoting prostaglandins (NEPPs) and other electrophilic compounds bind to Keap1, a negative regulator of the transcription factor Nrf2, and prevent Keap1-mediated inactivation of Nrf2 and, thus, enhance Nrf2 translocation into the nucleus of neuronal cells. Therefore, neuroprotective compositions and related methods are provided that employ such neuroprotective compounds, and prodrugs of such compounds, to cause dissociation of Nrf2 from a Keap1/Nrf2 complex.
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