Altering net charge on mannosylated dextrans to maximize target tissue uptake and off target competitive blocking

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United States of America Patent

PATENT NO 11833170
APP PUB NO 20230248757A1
SERIAL NO

18164296

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Abstract

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Provided are compounds, compositions, methods, and kits for increasing target specificity of a mannosylated carbohydrate polymeric therapeutic or diagnostic compound to reduce or eliminate localization of the mannosylated carbohydrate polymeric therapeutic or diagnostic compound to off-target sites. Mannosylated carbohydrate polymers are synthesized to be modified to be either polyanionic (i.e., net negatively charged) or electrostatically neutral, and using these polyanionic or neutral mannosylated carbohydrate polymers as competitors for polycationic (i.e., net positively charged) mannosylated carbohydrate polymers carrying small molecule drug payloads or imaging moieties to CD206 expressing cells in target tissues, such as tumors or other sites of inflammation.

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Patent Owner(s)

Patent OwnerAddress
NAVIDEA BIOPHARMACEUTICALS INC4995 BRADENTON AVENUE SUITE 240 DUBLIN OH 43017

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arnold, Jeffrey Scott Andover, US 5 0
Ralph, David A Columbus, US 17 2

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