4-phenylpiperdine-pyrazole CCR1 antagonists
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United States of America Patent
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Aug 18, 2009
Grant Date -
Apr 19, 2007
app pub date -
Oct 11, 2006
filing date -
Oct 11, 2005
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Abstract
Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally monocyclic and bicyclic compounds and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
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