Microfluidic chip and method for making the same

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United States of America Patent

PATENT NO 11707736
APP PUB NO 20210138459A1
SERIAL NO

16766536

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Abstract

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There is a described a patch-clamp chip for making electrical measurements on a biological sample. The patch-clamp chip comprising a plurality of layers comprising poly-dimethylsiloxane (PDMS) forming a stack. It comprises at least a chip surface layer comprising an aperture formed therethrough and which upwardly opens on the surface, where the biological sample is provided. A microfluidic channel layer comprising PDMS extends below the plane of the chip surface layer and comprises a microfluidic channel formed therein. The aperture of the chip surface layer downwardly opens on the microfluidic channel. Electrophysiological measurements are made between an internal solution in the microfluidic channel and the external solution on the chip surface. The measurements can be performed via a bottom electrode. A plurality of apertures and corresponding microfluidic channels can be provided to perform simultaneous measurements on a plurality of samples, independently.

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Patent Owner(s)

  • ENUVIO INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
McGuire, Hugo Montreal, CA 1 0

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