Pre-organized tricyclic integrase inhibitor compounds
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United States of America Patent
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Aug 7, 2007
Grant Date -
Aug 26, 2004
app pub date -
Oct 16, 2003
filing date -
Oct 16, 2002
priority date (Note) -
Expired
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Abstract
Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. ##STR00001## A.sup.1 and A.sup.2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, .sup.+NR, or CR.sup.4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.
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