Treatment of B cell cancers using a combination comprising Btk inhibitors

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United States of America Patent

PATENT NO 11701357
APP PUB NO 20210275530A1
SERIAL NO

16326467

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Abstract

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Disclosed herein is a method for the prevention, delay of progression or treatment of cancer in a subject, comprising administering to the subject in need thereof a Btk inhibitor, particularly, (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor or a targeted therapy agent. Also, disclosed a pharmaceutical combination comprising a Btk inhibitor, particularly, (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof, in combination with an immune checkpoint inhibitor, or a targeted therapy agent and the use thereof.

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Patent Owner(s)

  • BEIGENE SWITZERLAND GMBH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Guo, Yunhang Beijing, CN 34 314
Hu, Nan Beijing, CN 181 1182
Li, Kang Beijing, CN 157 1483
Luo, Lusong Beijing, CN 8 47
Song, Jing Beijing, CN 54 748
Wang, Lai Beijing, CN 53 1321
Wang, Zhiwei Beijing, CN 193 845
Wei, Min Beijing, CN 121 854
Zhang, Tong Beijing, CN 403 6941

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