Human patched genes and proteins, and uses related thereto
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United States of America Patent
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Aug 12, 2003
Grant Date -
Oct 31, 2002
app pub date -
Jul 19, 2001
filing date -
Dec 8, 1997
priority date (Note) -
Expired
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Abstract
The present invention relates to the discovery of a new member of the hedgehog receptor family, referred to herein as human ptc-2 (for patched-2 protein). The human ptc-2 polypeptides of the present invention include polypeptides which bind the products of the hedgehog gene family. Hedgehog family members are known for their broad involvement in the formation and maintenance of ordered spatial arrangements of differentiated tissues in vertebrates, both adult and embryonic, and can be used to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
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