Non-chromatographic purification of macrocyclic peptides by a resin catch and release

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11479581
APP PUB NO 20210079046A1
SERIAL NO

16618847

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

The disclosure is directed to compounds and methods for preparing purified macrocyclic peptide using “catch-release” methods. These methods comprise reacting a free amino group of a resin-bound linear peptide with an azide- or alkyne-functionalized cap to form a resin-bound capped linear peptide having an azide- or alkyne-functionalized cap; cleaving the capped linear peptide from the resin to form a free capped linear peptide having an azide- or alkyne-functionalized cap; reacting the free capped linear peptide having an azide-functionalized cap with an alkyne-functionalized catch resin, or reacting the free capped linear peptide having an akynyl-functionalized cap with an azide functionalized catch resin, to form a catch-resin bound capped linear peptide; reacting the catch-resin bound capped linear peptide under conditions sufficient to effect macrocyclization of the linear peptide and release of the macrocyclic peptide from the catch resin.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
BRISTOL-MYERS SQUIBB COMPANYROUTE 206 AND PROVINCE LINE ROAD PRINCETON NJ 08543

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Carter, Percy H Princeton, US 39 220
Creech, Gardner S North Holland, NL 2 0
Eastgate, Martin D Titusville, US 27 24
Kheirabadi, Mahboubeh Cambridge, US 5 2
Nirschl, David S Yardley, US 2 0

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 Apr 25, 2026
7.5 Year Payment $3600.00 $1800.00 $900.00 Apr 25, 2030
11.5 Year Payment $7400.00 $3700.00 $1850.00 Apr 25, 2034
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00