Use of des-aspartate-angiotensin I as an anti-cardiac hypertrophic agent
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United States of America Patent
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Jun 30, 1998
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N/A
app pub date -
May 19, 1997
filing date -
May 25, 1995
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Expired
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Abstract
The use of des-Aspartate-angiotensin I (Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) as an anti-cardiac hypertrophic agent is described. The compound, given either intravenously or orally, prevented the development of experimentally-induced cardiac hypertrophy in rats. Its action was dose-dependent and the maximum anti-cardiac hypertrophic effect was obtained at a dose of(i) 180 ng/day when given intravenously, and (ii) 285 .mu.g/day when given orally.
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