Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia
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United States of America Patent
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Aug 24, 2004
Grant Date -
May 8, 2003
app pub date -
Jul 29, 2002
filing date -
Feb 20, 1998
priority date (Note) -
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Abstract
This invention relates to a series of heterocyclic substituted piperazines of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the .alpha.-1.sub.a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.
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