Inhibitors of fatty acid amide hydrolase
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United States of America Patent
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Feb 16, 2010
Grant Date -
May 25, 2006
app pub date -
Oct 8, 2003
filing date -
Oct 8, 2002
priority date (Note) -
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Abstract
Improved competitive inhibitors of FAAH employ an α-keto heterocyclic pharmacophore and a binding subunit having a ?-unsaturation. The α-keto heterocyclic pharmacophore and a binding subunit are attached to one another, preferably by a hydrocarbon chain. The improvement lies in the use of a heterocyclic pharmacophore selected from oxazoles, oxadiazoles, thiazoles, and thiadiazoles that have alkyl or aryl substituents at their 4 and/or 5 positions. The improved competitive inhibitors of FAAH display enhanced activity over conventional competitive inhibitors of FAAH.
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