Methods for producing ex vivo models for inflammatory disease and uses thereof
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United States of America Patent
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Oct 14, 2008
Grant Date -
Nov 29, 2007
app pub date -
Jul 16, 2007
filing date -
Sep 6, 2001
priority date (Note) -
Expired
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Abstract
The invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with one or more cytokines, e.g., IL-.beta., TNF.alpha. or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to methods for identifying genes that correlate with various pro-asthma/pro-inflammatory disease phenotypes.
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