Hypocholesterolemic hydrogenation products and process of preparation
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United States of America Patent
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Sep 28, 1982
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N/A
app pub date -
Dec 1, 1980
filing date -
Feb 4, 1980
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Expired
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Abstract
Hydrogenation of the natural fermentation product, mevinolin, MK-803, results in the production of dihydro- and tetra-hydro derivatives and hydrogenation of the naturally occurring dihydromevinolin results in the formation of a tetrahydro derivative. These several products with the exception of cis-(4.alpha..beta., 8.alpha..beta.-)-tetrahydromevinolin are potent inhibitors of cholesterol biosynthesis.
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