Serine protease variants having peptide ligase activity
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United States of America Patent
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Apr 7, 1998
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app pub date -
Jun 7, 1995
filing date -
Aug 9, 1990
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Abstract
The invention relates to serine protease variants derived from precursor serine proteases via recombinant and/or chemical methods to form protease variants having improved peptide ligase activity. The invention also includes novel ligation substrates which in combination with the serine protease variants and a second ligation substrate are capable of forming a ligation product. The invention also relates to methods for forming such ligation products and the products formed thereby.
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