Process for the preparation of isosorbide-5-nitrate
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United States of America Patent
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Feb 14, 1984
Grant Date -
N/A
app pub date -
Apr 23, 1982
filing date -
May 5, 1981
priority date (Note) -
Expired
status (Latency Note)
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Abstract
In a process for preparing isosorbide-5-nitrate, isosorbide is reacted with an aliphatic carboxylic acid, with the formation of an acylation mixture. The acylation mixture is then nitrated, and the resulting nitration mixture is hydrolyzed and/or transesterified in order to split off acyl groups. The product is used in treatment of angina pectoris.
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