Compositions and methods of inhibiting gene expression in a lung

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United States of America Patent

PATENT NO 11377657
APP PUB NO 20210261967A1
SERIAL NO

16883667

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides compositions and methods for delivery to a lung tissue comprising a small interfering RNA (siRNA) capable of inhibiting expression of a gene, and a surfactant. In one aspect, a non-polymeric methods composition comprising a small interfering RNA (siRNA) capable of inhibiting expression of a gene, and a surfactant is disclosed. In other aspects, a method of inhibiting gene expression in a lung of a subject in need thereof and treating bronchopulmonary dysplasia in a lung of a subject also disclosed. The methods comprise administering a therapeutically effective amount of a non-polymeric composition to the lung of the subject, wherein the non-polymeric composition comprises a small interfering RNA (siRNA) capable of inhibiting expression of a gene, and a surfactant.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bhandari, Vineet Lansdale, US 4 11

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