Beta-lactamase inhibitor prodrug
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United States of America Patent
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Aug 15, 2006
Grant Date -
Jun 10, 2004
app pub date -
Aug 25, 2003
filing date -
Aug 23, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Prodrugs of 6-.beta.-hydroxymethylpenicillanic acid sulfone having the structure ##STR00001## wherein R is H or methyl, and solvates thereof, are disclosed. Also disclosed are pharmaceutical compositions comprising a prodrug of the present invention or a solvate thereof, an optional beta-lactam antibiotic and a pharmaceutically acceptable excipient.Further disclosed is a method for increasing the therapeutic effectiveness of a beta-lactam antibiotic in a mammal by administering an effective amount of a beta-lactam antibiotic and an effectiveness-increasing amount of a prodrug of the present invention, or a solvate thereof.Additionally disclosed is a method for treating a bacterial infection in a mammal by administering a therapeutically effective amount of a pharmaceutical composition of the present invention to a mammal in need thereof.
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