Agent for inducing apoptosis comprising MSX1 or a gene encoding the same as an active ingredient
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United States of America Patent
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May 22, 2012
Grant Date -
Apr 2, 2009
app pub date -
Oct 17, 2008
filing date -
Jul 22, 2005
priority date (Note) -
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Abstract
The present invention relates to a novel use of Msx1 protein or a nucleotide encoding the same for inducing apoptosis. The Msx1 of the present invention induces apoptosis through direct interaction with p53 via a homeodomain and such interaction leads to increased stability, and/or nuclear localization of p53 in cells. The Msx1 or homeodomain thereof can be effectively used for the treatment of tumors, in which wild-type p53 protein has lost its function by some mechanism that inactivates p53 proteins.
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