Method for monitoring kinase activity in a sample

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United States of America Patent

PATENT NO 11624082
APP PUB NO 20210262007A1
SERIAL NO

17254116

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Abstract

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The present invention relates to a method for monitoring kinase activity or activation in a sample, the method comprises the steps of a) providing a sample comprising a kinase, b) incubating the sample with a protease to cleave the kinase provided in step a) into protease specific proteolytic peptides, c) applying phosphopeptide enrichment to the sample, d) analysing the sample obtained in step c) via liquid chromatography-mass spectrometry, and e) detecting phosphorylations of the kinase provided in step a), wherein the detection of step e) is performed only in case a proteolytic peptide associated with the activation region of the kinase is identified.

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Patent Owner(s)

  • UNIVERSITEIT UTRECHT HOLDING B. V.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Altelaar, Adrianus Fredrik Maarten Utrecht, NL 1 0
Schmidlin, Thierry Thomas Utrecht, NL 1 0

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