Anti-pleiotrophin antibodies and methods of use thereof
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United States of America Patent
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Feb 15, 2011
Grant Date -
Nov 25, 2004
app pub date -
Mar 26, 2004
filing date -
Mar 26, 2003
priority date (Note) -
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Abstract
The present invention concerns antibodies that neutralize at least one biological activity of pleiotrophin. The antibodies can inhibit cancer cell growth and angiogenesis in vitro or in vivo. The present invention provides for methods of inhibiting cancer cell growth or angiogenesis in a subject comprising administering to said subject an effective amount of the antibodies described herein. The present invention also provides for methods of making the neutralizing antibodies described herein.
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