Phosphorothioate-conjugated miRNAs and methods of using the same

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United States of America Patent

PATENT NO 11857633
SERIAL NO

17217989

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Abstract

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Provided herein are, inter alia, nucleic acid conjugates including a non-cell penetrating ribonucleic acid compound attached at its 3′ end to a phosphorothioate polymer. Attachment of the phosphorothioate polymer to the non-cell penetrating ribonucleic acid conveys stability to and allows for efficient intracellular delivery of the non-cell penetrating ribonucleic acid. The nucleic acid conjugates provided herein including embodiments thereof are useful, inter alia, for the treatment of cancer, inflammatory disease, and pain.

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  • CITY OF HOPE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Herrmann, Andreas Del Mar, US 200 725
Yu, Hua Glendora, US 117 838

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