Compositions and methods for enhancing drug delivery across and into epithelial tissues
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United States of America Patent
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Jan 7, 2014
Grant Date -
Aug 25, 2011
app pub date -
Jun 15, 2010
filing date -
Aug 24, 1999
priority date (Note) -
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Abstract
This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length.
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